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 Drug overdose deaths increased more than 17 percent between 2015 and 2016, according to a new report by the Centers for Disease Control and Prevention (CDC).

The overdose death rate rose to almost 20 people per 100,000, up from 16.3 per 100,000 the previous year, The New York Times reports.

Drug overdoses are now the leading cause of death for Americans under age 50, the CDC found.

Recently, these deaths have been driven by overdoses of fentanyl and other synthetic opioids, according to Dr. Robert Anderson, Chief of the CDC mortality statistics branch. “The main message is the drug rate went up a lot again, and of course we’re worried about it,” he said.

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Original author: Ezra